B‘SYS is equipped with state of the art patch-clamp technology. Our setups are equipped with systems for rapid drug application.

Further options for your experiments:

• Full glass equipment
• Temperature control
• Full human plasma or in the presence of BSA or other relevant proteins

Application schemes and assay conditions can be adapted for your needs.

Depending on the application scheme  and the type of ion channel the manual setups at B'SYS allow the measurement of 20-50 compounds per day.

Whole-cell recordings or single-channel analysis in various expression systems (HEK 293, CHO, Neuroblastoma etc.) can be conducted to test the effects of drugs on voltage-gated or ligand-gated ion channels.

B'SYS currently operates 3 automated patch clamp devices (Sophion Qpatch™).

Please contact us for details or offers: [email protected]

For details, please check our catalog.

 

Voltage gated ion Channels (VGIC)

 

Ligand gated ion receptors

 

Cardiac Panel / Comprehensive in Vitro Proarrhytmia Assay (CiPA)

 

 

Voltage gated ion channel (VGIC)

 

 

Potassium Channels

Channel	Gene	Manual	Automated
KV1.1	KCNA1
KV1.2	KCNA2
KV1.3	KCNA3
KV1.4	KCNA4
KV1.5	KCNA5
KV1.6	KCNA6
KV1.7	KCNA7
KV2.1	KCNB1
KV2.2	KCNB2
KV3.1a (short)	KCNC1
KV3.1b (long)	KCNC1
KV3.2	KCNC2
KV3.3	KCNC3
KV3.4	KCNC4
KV4.2	kCND2
KV4.3	KCND3
KV4.3 / KChiP	KCND3 / KCNIP2
KV7.1	KCNQ1
KV7.1 / minK	KCNQ1 / MINK
KV7.2	KCNQ2
KV7.3	KCNQ3
KV7.2 / 7.3	KCNQ2/3
KV7.3 / 7.5	KCNQ3/5
KCa2.1	KCNN1
KCa3.1	KCNN4
KCa4.1	KCNT1
K2P1.1	KCNK1
K2P18.1	KCNK18
KV11.1 (hERG)	KCNH2
hERG Duo	KCNH2
Kir2.1	KCNJ2
Kir2.2	KCNJ12
Kir2.3	KCNJ4
Kir3.1	KCNJ3
Kir3.4	KCNJ5
BK	KCNMA1
Neuroblastoma whole potassium channels (N1E-115)

 

HCN Channels

Channel	Gene	Manual	Automated
HCN1	HCN1
HCN2	HCN2
HCN3	HCN3
HCN4	HCN4

 

Sodium Channels

Channel	Gene	Manual	Automated
NaV1.1	SCN1A
NaV1.2	SCN2A
NaV1.3	SCN3A
NaV1.4	SCN4A
NaV1.5	SCN5A
NaV1.5 big late	SCN5A
NaV1.6	SCN8A
NaV1.7	SCN9A
NaV1.8	SCN10A
NaV1.9	SCN11A
Neuroblastoma whole sodium (TTX sensitive sodium channels)

 

Calcium Channels

Channel	Gene	Manual	Automated
CaV1.2	CACNA1C / CACNB2 / CACNA2D
CaV1.3	CACNA1D / CACNB3 / CACNA2D
CaV2.1	CACNA1A / CACNB3 / CACNA2D2 or CACNA2D4
CaV3.1	CACNA1G
CaV3.2	CACNA1H
CaV3.3	CACNA1I
Neuroblastoma whole calcium (T- and L- type)

 

Chloride Channels

Channel	Gene	Manual	Automated
ClC-2	CLCN2
CFTR	CFTR

 

TRP Channels

Channel	Gene	Manual	Automated
TRPA1	TRPA1
TRPM4	TRPM4
TRPM8	TRPM8
TRPV1	TRPV1 (VR1)
mTRPV1 (mouse)	Trpv1
TRPV2	TRPV2
TRPV3	TRPV3
TRPV4	TRPV4	coming soon	coming soon

 

 

Ligand gated ion receptors

 

GABAA Receptors

Channel	Gene	Manual	Automated
GABAA (α1β2γ2)	GABRA1 / GABRB2 / GABRG2
GABAA (α1β3γ2)	GABRA1 / GABRB3 / GABRG2
GABAA (α2β2γ2)	GABRA2 / GABRB2 / GABRG2
GABAA (α3β2γ2)	GABRA3 / GABRB2 / GABRG2
GABAA (α4β3d)	GABRA4 / GABRB3 / GABRD
GABAA (α5β2γ2)	GABRA5 / GABRB2 / GABRG2
GABAA (α6β3d)	GABRA6 / GABRB3 / GABRD
GABAA (β3)	GABRB3

 

Glutamate Receptors

Channel	Gene	Manual	Automated
AMPA	GRIA1
Kainate K1	GRIK1
Kainate K2	GRIK2
Kainate K2/K5	GRIK2/5
NMDA (NR1 / 2A)	GRIN1 / GRIN2A
NMDA (NR1 / 2B)	GRIN1 / GRIN2B
NMDA (NR1 / 2C)	GRIN1 / GRIN2C
NMDA (NR1 / 2D)	GRIN1 / GRIN2D

 

Acetylcholine Receptors

Channel	Gene	Manual	Automated
nAChR (α7)	CHRNA7
nAChR (α3β4)	CHRNA3 / CHRNB4
nAChR (α4β2)	CHRNA4 / CHRNB2

 

P2X Receptors

Channel	Gene	Manual	Automated
P2X1	P2RX1
P2X2	P2RX2
P2X3	P2RX3
P2X2/3	P2RX2/P2RX3
P2X4	P2RX4
P2X7	P2RX7

 

Glycine Receptors

Channel	Gene	Manual	Automated
GlyRα1	GLYRA1
GlyRα2	GLYRA2
GlyRα3	GLYRA3
GlyRα3β	GLYRA3B

 

Serotonine Receptors

Channel	Gene	Manual	Automated
5HT3A	5HT3A
5HT3A/B	5HT3A / 5HT3B

 

Acid sensing Receptors

Channel	Gene	Manual	Automated
ASIC1 isoform 1 (1a long)	ACCN2
ASIC1 isoform 2 (1a short)	ACCN2
ASIC1 isoform 3 (1b)	ACCN2
ASIC2	ACCN1
ASIC3	ACCN3