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Kv1.5
Gene: KCNA5
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Standard throughput time | 2-4 weeks (draft) |
| Source | human | |
| Expression system | mammalian (CHO), stable expression | |
| Method | manual and automated patch-clamping and fluorescence (FlexStation/FLIPR) | |
| Quality level | high quality functional assay and fluorescence assay |
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| Reference | Terfenadine (IC50: 2.9 µM), Nifedipine (IC50: 45.5 µM), S9947 (IC50 steady state: 0.6 µM, IC50 peak current: 17.6 µM) |
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References, further examples |
Besartan, Aminodarone, Diclofenac, Meclo fenamate | |
| + Cardiac toxicity / safety relevant ion channel test |
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| + Antiarrhytmic screening |
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