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Late Nav1.5 current
Gene: SCN5A
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Standard throughput time | 2-4 weeks (draft) |
Source | human | |
Expression system | mammalian (HEK), stable expression |
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Method | manual and automated patch-clamping |
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Quality level | high quality functional assay |
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Reference |
Flecainide (IC50 Peak: 43.08 µM, IC50 Late: 0.23 µM), Lidocaine(IC50 Peak: 446.01 µM, IC50 Late: 16.88 µM), Mexiletine(IC50 Peak: 48.49 µM, IC50 Late: 11.94 µM) |
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References, further examples | Ranolazine, TTX | |
+ Cardiac toxicity / safety relevant ion channel test |
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+ Antiarrhythmic screening |