Swiss Quality in Ion channel Services

Late Nav1.5 current

Gene: SCN5A

Late NaV1.5 Current repres
Standard throughput time 2-4 weeks (draft)
Source human
Expression system mammalian (HEK), stable expression
Method manual and automated patch-clamping
Quality level high quality functional assay
Reference

Flecainide (IC50 Peak: 43.08 µM, IC50 Late: 0.23 µM),

Lidocaine(IC50 Peak: 446.01 µM, IC50 Late: 16.88 µM),

Mexiletine(IC50 Peak: 48.49 µM, IC50 Late: 11.94 µM)

References, further examples Ranolazine, TTX
+  Cardiac toxicity / safety relevant ion channel test
+  Antiarrhythmic screening