CiPA

B‘SYS is organized as GLP (Good Laboratory Practice) test facility and is since 2004 thus reliably provides ion channel services in compliance with GLP principles for regulatory submission of compliant data. All GLP studies are supported by method validation procedures providing solid evidence of method suitability for regulatory purposes. 

GLP Cardiac AP

 

GLP validated patch clamp assays

Target/Assay Test System Validated reference compound
hERG / peak tail current CHO / HEK 293 E-4031
hERG / trafficking CHO Pentamidine
NaV1.5 / peak current CHO Propafenone / Quinidine
NaV1.5 / late current CHO Anthopleurin C
NaV1.5 / ATXII activated late current CHO Ranolazine
CaV1.2 / peak current CHO Nifedipine
KV7.1 / minK / steady state current HEK 293 JNJ 303

 

 

GLP validated CiPA patch clamp assays

Measured according to the CiPA protocols.

Target/Assay Test System Validated reference compound
hERG CHO Verapamil
hERG / trafficking CHO Pentamidine
NaV1.5 CHO Quinidine
NaV1.5 / ATXII activated late current CHO Ranolazine
CaV1.2 CHO Nifedipine / Verapamil
KV1.5 CHO S 9947

 

 

Assay design and application schemes can be adapted to your needs.

Available options for GLP-assays:

  • Full glass equipment
  • Temperature control (RT or physiological temperature)
  • Solubility tests
  • Dose formulation analysis (GLP or non-GLP)

For more details or offers, please contact us: [email protected]