BSYS | NaV1.5

Na_v1.5

Gene: SCN5A

	Standard throughput time	2-4 weeks (draft)
	Source	human
	Expression system	mammalian (CHO), stable expression
	Method	manual and automated patch-clamping
	Quality level	high quality functional assay
	Reference	Quinidine (IC₅₀: 13.6 µM), Propafenone (IC₅₀: 1.5 µM), Carbamazepine (IC₅₀: 59.2 µM), TTX (IC₅₀: 6.0 µM),
	References, further examples	Mibefradil, Lidocaine, TTX
	+ Cardiac toxicity / safety relevant ion channel test
	+ Antiarrhythmic screening