BSYS | Cell Lines

All recombinant ion channel targets are fully validated and available for screening purposes. B‘SYS continuously expands its library of ion channels. Please contact us for more information about other ion channel targets not outlined in the table below. [email protected]

Voltage gated ion channels (VGIC)

Potassium Channels

BK α1KCNMA1-CHOconstitutive

Target	Gene	Disorder	Cell Type	Expression
K_V1.1	KCNA1	Seizure disorders	CHO	constitutive
K_V1.2	KCNA2	Seizure disorders	CHO	constitutive
K_V1.3	KCNA3	Immune system related	CHO	constitutive
K_V1.4	KCNA4	-	CHO	constitutive
K_V1.5	KCNA5	Heart function	CHO	constitutive
K_V1.6	KCNA6	-	CHO	constitutive
K_V1.7	KCNA7	-	CHO	constitutive
K_V2.1	KCNB1	-	CHO	constitutive
K_V2.1	KCNB1		HEK 293	inducible
K_V2.2	KCNB2	-	CHO	constitutive
K_V2.2	KCNB2	-	HEK 293	inducible
K_V3.1a (short)	KCNC1	-	CHO	constitutive
K_V3.1b (long)	KCNC1	-	CHO	constitutive
K_V3.2	KCNC2	-	CHO	inducible
K_V3.3	KCNC3	-	CHO	constitutive
K_V3.4	KCNC4	-	CHO	inducible
K_V4.2	KCND2	-	CHO	constitutive
K_V4.3	KCND3	-	CHO	constitutive
K_V4.3	KCND3	-	HEK 293	inducible
K_V4.3 KChip	KCND3	-	CHO	constitutive
K_V7.1 (K_VLQT1)	KCNQ1	-	HEK 293	inducible
K_V7.1 (K_VLQT1)	KCNQ1	LQT Syndrome 1/5	HEK 293	constitutive
K_V7.1 (K_VLQT1)	KCNQ1	LQT Syndrome 1/5	CHO	constitutive
K_VLQT1/minK	KCNQ1/KCNE1	LQT Syndrome 1/5	HEK 293	constitutive
K_VLQT1/minK	KCNQ1/KCNE1	LQT Syndrome 1/5	CHO	constitutive
K_V7.2	KCNQ2	Epilepsy	CHO	constitutive
K_V7.3	KCNQ3	Epilepsy	CHO	constitutive
K_V7.2/3	KCNQ2/3	Epilepsy	CHO	constitutive
K_V7.2/3 (rat)	KCNQ2/3	Epilepsy	CHO	constitutive
K_V7.3/5	KCNQ3/5	-	CHO	constitutive
K_V10.1	KCNH1	-	CHO	constitutive
K_2P18.1	KCNK18	-	HEK 293	constitutive
SK4 K_Ca3.1	KCNN4	-	CHO	inducible
hERG	KCNH2	LQT Syndrome 2	HEK 293	inducible
hERG	KCNH2	LQT Syndrome 2	HEK 293	constitutive
hERG	KCNH2	LQT Syndrome 2	CHO	inducible
hERG	KCNH2	LQT Syndrome 2	CHO	constitutive
hERG Duo	KCNH2	LQT Syndrome 2	CHO	constitutive
Kir1.1	KCNJ1	-	CHO	constitutive
Kir2.1	KCNJ2	LQT Syndrome	CHO	constitutive
Kir2.2	KCNJ12	-	CHO	constitutive
Kir2.3	KCNJ4	-	HEK 293	constitutive
Kir2.3	KCNJ4	-	CHO	constitutive
BK α1	KCNMA1	-	CHO	constitutive
BK α1	KCNMA1	-	CHO	inducible
BK α1β2	KCNMA1 / KCNMB2	-	CHO	inducible
BK α1β4	KCNMA1 / KCNMB4	-	CHO	inducible
K_Ca2.2 (SK2)	KCNN1	-	CHO	constitutive
K_Ca2.1 / K_Ca2.2 (SK1/SK2)	KCNN2 / KCNN1	-	CHO	constitutive

HCN Channels

Target	Gene	Disorder	Cell Type	Expression
HCN1	HCN1	-	HEK 293	inducible
HCN2	HCN2	-	HEK 293	inducible
HCN2 (rat)	HCN2	-	HEK 293	inducible
HCN4	HCN4	-	HEK 293	inducible
HCN4 (rat)	HCN4	-	HEK 293	inducible

Sodium Channels

Target	Gene	Disorder	Cell Type	Expression
Na_V1.1	SCN1A	-	CHO	constitutive
Na_V1.2	SCN2A	-	CHO	constitutive
Na_V1.3	SCN3A	Epilepsy / Pain	CHO	constitutive
Na_V1.4	SCN4A	-	HEK 293	inducible
Na_V1.4	SCN4A	-	CHO	constitutive
Na_V1.5	SCN5A	LQT Syndrome 3	HEK	constitutive
Na_V1.5	SCN5A	LQT Syndrome 3	HEK	inducible
Na_V1.5 duo	SCN5A	LQT Syndrome 3	CHO	constitutive
Na_V1.5 big late	SCN5A L409C/A410W	LQT Syndrome 3	HEK 293	constitutive
Na_V1.5 ΔKPQ	SCN5A ΔKPQ	LQT Syndrome 3	HEK	constitutive
Na_V1.6	SCN8A	-	CHO	constitutive
Na_V1.7	SCN9A	-	CHO	constitutive
Na_V1.7	SCN9A	-	CHO	inducible
Na_V1.8	SCN10A/SCN3B	-	CHO	constitutive
Na_V1.9	SCN11A	-	HEK	inducible

Calcium Channels

Target	Gene	Disorder	Cell Type	Expression	Datasheet
CaV1.2	CACNA1C/CACNB2/ CACNA2D	-	HEK 293	inducible
CaV3.1	CACNA1G	-	CHO	constitutive
CaV3.2	CACNA1H	-	HEK 293	constitutive
CaV3.3	CACNA1I	-	HEK 293	constitutive	-

Chloride Channels

Target	Gene	Disorder	Cell Type	Expression
CFTR	CFTR	-	CHO	constitutive
CFTR	CFTR	-	HEK 293	inducible
ClC-1	CLCN1	-	HEK 293	inducible
ClC-1	CLCN1	-	CHO	constitutive

TRP Channels

Target	Gene	Disorder	Cell Type	Expression
TRPA1	TRPA1	-	HEK 293	inducible
TRPV1	TRPV1 (VR1)	-	CHO	constitutive
TRPV1 (mouse)	TRPV1 (VR1)	-	CHO	constitutive
TRPV3	TRPV3	Olmsted syndrom	CHO	constitutive
TRPV3 (mouse)	TRPV3	Olmsted syndrom	CHO	constitutive
TRPV4	TRPV4	Dwarfism, Neuropathy	HEK 293	inducible
TRPV4 (mouse)	TRPV4	Dwarfism, Neuropathy	CHO	constitutive
TRPM4	TRPM4	-	CHO	constitutive
TRPM8	TRPM8	Pain sensation	HEK 293	constitutive

Ligand gated ion receptors

GABAA Receptors

Target	Gene	Disorder	Cell Type	Expression	Datasheet
GABA α₁β₂γ₂	GABRA1 / GABRB2 / GABRG2	-	CHO	constitutive
GABA α₂β₂γ₂	GABRA2 / GABRB2 / GABRG2	-	HEK	inducible

Glutamate Receptors

Target	Gene	Disorder	Cell Type	Expression
Kainate K2	GRIK2	-	CHO	constitutive
Kainate K2	GRIK2	-	HEK 293	inducible
NMDAR1	GRIN1	Mental retardation	CHO	inducible
NMDA 1/2A	GRIN1/GRIN2A	Epilepsy	HEK 293	inducible
NMDA 1/2B	GRIN1/GRIN2B	Depression	HEK 293	inducible
NMDA 1/2D	GRIN1/GRIN2D	-	HEK 293	inducible

Acetylcholine Receptors

Target	Gene	Disorder	Cell Type	Expression	Datasheet
nAChR α₄β₂	CHRNA4 / CHRNB2	-	CHO	constitutive

P2X Receptors

Target	Gene	Disorder	Cell Type	Expression
P2X1	P2rx1	-	CHO	constitutive
P2X2	P2rx2	-	CHO	constitutive
P2X2/3	P2rx2/P2rx3	-	CHO	constitutive
P2X3	P2rx3	-	CHO	constitutive
P2X4	P2rx4	-	HEK 293	constitutive
P2X7	P2rx7	-	HEK 293	constitutive

Glycine Receptors

Target	Gene	Disorder	Cell Type	Expression
GlyRα1 (h)	GLRA1	-	CHO	constitutive
GlyRα2 (r)	GLRA2	-	CHO	constitutive
GlyRα3 (h)	GLRA3	Pain sensation	HEK 293	inducible
GlyRα3 (h)	GLRA3	Pain sensation	CHO	constitutive
GlyRα3 (r)	GLRA3	Pain sensation	CHO	constitutive

Serotonine Receptors

Target	Gene	Disorder	Cell Type	Expression	Datasheet
5HT3A	5HT3A	-	CHO	constitutive

Acid sensing Receptors

Target	Gene	Disorder	Cell Type	Expression
ASIC1 isoform a	ACCN2	-	CHO	constitutive
ASIC1 isoform b	ACCN2	-	CHO	constitutive
ASIC1 isoform c	ACCN2	-	CHO	constitutive
ASIC3	ACCN3	-	CHO	constitutive

Miscellaneous Channels

Target	Gene	Disorder	Cell Type	Expression
VDAC	VDAC1	-	CHO	constitutive
PEPT1	SLC15A1	-	MDCK	constitutive
Stargazin	CACNG2	Seizure disorders	HEK 293	constitutive

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