Swiss Quality in Ion channel Services

Cell Lines

All recombinant ion channel targets are fully validated and available for screening purposes. B‘SYS continuously expands its library of ion channels. Please contact us for more information about other ion channel targets not outlined in the table below. [email protected]

Voltage gated ion channels (VGIC)

Potassium HCN Sodium Calcium Chloride TRP

 

Ligand gated ion receptors

GABAA Glutamate Acetylcholine P2X Glycine Serotonine Acid sensing

 

Cardiac Panel / Comprehensive in Vitro Proarrhytmia Assay (CiPA)

CiPa

 

Miscellaneous

 

Voltage gated ion channels (VGIC)

 

Potassium Channels

BK α1KCNMA1-CHOconstitutive

Target Gene Disorder Cell Type Expression Datasheet
KV1.1  KCNA1 Seizure disorders CHO constitutive CHO Kv1.x
KV1.2  KCNA2 Seizure disorders CHO constitutive CHO Kv1.x
KV1.3  KCNA3 Immune system related CHO constitutive CHO Kv1.3
KV1.4  KCNA4 - CHO constitutive CHO Kv1.x
KV1.5  KCNA5 Heart function CHO constitutive CHO Kv1.x
KV1.6  KCNA6 - CHO constitutive CHO Kv1.x
KV1.7  KCNA7 - CHO constitutive  
KV2.1  KCNB1 - CHO constitutive CHO Kv2.1
KV2.1 KCNB1   HEK 293 inducible  
KV2.2  KCNB2 - CHO constitutive  
KV2.2  KCNB2 - HEK 293 inducible  
KV3.1a (short) KCNC1 - CHO constitutive  
KV3.1b (long) KCNC1 - CHO constitutive  
KV3.2 KCNC2 - CHO inducible  
KV3.3 KCNC3 - CHO constitutive  
KV3.4 KCNC4 - CHO inducible  
KV4.2  KCND2 - CHO constitutive  
KV4.3  KCND3 - CHO constitutive CHO Kv4.3
KV4.3  KCND3 - HEK 293 inducible  
KV4.3 KChip  KCND3 - CHO constitutive CHO Kv4.3 KChIP
KV7.1 (KVLQT1) KCNQ1 - HEK 293  inducible  
KV7.1 (KVLQT1) KCNQ1 LQT Syndrome 1/5 HEK 293 constitutive  
KV7.1 (KVLQT1) KCNQ1 LQT Syndrome 1/5 CHO constitutive  
KVLQT1/minK  KCNQ1/KCNE1 LQT Syndrome 1/5 HEK 293 constitutive HEK KvLQT1/minK
KVLQT1/minK KCNQ1/KCNE1 LQT Syndrome 1/5 CHO constitutive CHO KvLQT1/minK
KV7.2  KCNQ2 Epilepsy CHO constitutive CHO Kv7.2
KV7.3  KCNQ3 Epilepsy CHO constitutive  
KV7.2/3  KCNQ2/3 Epilepsy CHO constitutive CHO Kv7.2/3
KV7.2/3  (rat) KCNQ2/3 Epilepsy CHO constitutive  
KV7.3/5  KCNQ3/5 - CHO constitutive  
KV10.1 KCNH1 - CHO constitutive  
K2P18.1 KCNK18 - HEK 293 inducible HEK K2P18.1 TRESK
SK4 KCa3.1 KCNN4 - CHO inducible  
hERG KCNH2 LQT Syndrome 2 HEK 293 inducible HEK-Tet hERG
hERG  KCNH2 LQT Syndrome 2 HEK 293 constitutive HEK 293 hERG
hERG  KCNH2 LQT Syndrome 2 CHO inducible CHO-Tet hERG
hERG  KCNH2 LQT Syndrome 2 CHO constitutive CHO-Tet hERG
hERG Duo  KCNH2 LQT Syndrome 2 CHO constitutive CHO hERG DUO
Kir1.1  KCNJ1 - CHO constitutive  
Kir2.1  KCNJ2 LQT Syndrome CHO constitutive CHO Kir2.1
Kir2.2  KCNJ12 - CHO constitutive  
Kir2.3  KCNJ4 - HEK 293 constitutive  
Kir2.3  KCNJ4 - CHO constitutive  
BK α1 KCNMA1 - CHO constitutive  
BK α1 KCNMA1 - CHO inducible  
BK α1β2 KCNMA1 / KCNMB2 - CHO inducible  
BK α1β4 KCNMA1 / KCNMB4 - CHO inducible  
KCa2.2 (SK2) KCNN1 - CHO constitutive  
KCa2.1 / KCa2.2 (SK1/SK2) KCNN2 / KCNN1 - CHO constitutive  

HCN Channels

Target Gene Disorder Cell Type Expression Datasheet
HCN1 HCN1 - HEK 293 inducible HEK HCN1
HCN2 HCN2 - HEK 293 inducible HEK HCN2
HCN2 (rat) HCN2 - HEK 293 inducible  
HCN4  HCN4 - HEK 293 inducible HEK HCN4
HCN4  (rat) HCN4 - HEK 293 inducible  

Sodium Channels

Target Gene Disorder Cell Type Expression Datasheet
NaV1.1  SCN1A - CHO constitutive  
NaV1.2  SCN2A - CHO constitutive CHO NaV1.2
NaV1.3  SCN3A Epilepsy / Pain CHO constitutive  
NaV1.4  SCN4A - HEK 293 inducible  
NaV1.4 SCN4A - CHO constitutive CHO NaV1.4
NaV1.5 SCN5A LQT Syndrome 3 HEK constitutive  
NaV1.5 SCN5A LQT Syndrome 3 HEK inducible  
NaV1.5 duo  SCN5A LQT Syndrome 3 CHO constitutive CHO NaV1.5 DUO
NaV1.5 big late SCN5A L409C/A410W LQT Syndrome 3 HEK 293 constitutive HEK NaV1.5 big late
NaV1.5 ΔKPQ SCN5A ΔKPQ LQT Syndrome 3 HEK constitutive  
NaV1.6 SCN8A - CHO constitutive  
NaV1.7  SCN9A - CHO constitutive CHO NaV1.7
NaV1.7  SCN9A - CHO inducible  
NaV1.8  SCN10A/SCN3B - CHO constitutive CHO NaV1.8
NaV1.9  SCN11A - HEK inducible HEK NaV1.9

Calcium Channels

Target Gene Disorder Cell Type Expression Datasheet
CaV1.2  CACNA1C/CACNB2/ CACNA2D - HEK 293 inducible HEK CaV1.2
CaV3.1  CACNA1G - CHO constitutive CHO CaV3.1
CaV3.2  CACNA1H - HEK 293 constitutive HEK CaV3.2
CaV3.3  CACNA1I - HEK 293 constitutive -

Chloride Channels

Target Gene Disorder Cell Type Expression Datasheet
CFTR  CFTR - CHO constitutive  
CFTR  CFTR - HEK 293 inducible  
ClC-1 CLCN1 - HEK 293 inducible  
ClC-1 CLCN1 - CHO constitutive  

TRP Channels

Target Gene Disorder Cell Type Expression Datasheet
TRPA1 TRPA1 - HEK 293 inducible HEK TRPA1
TRPV1 TRPV1 (VR1) - CHO constitutive  
TRPV1 (mouse) TRPV1 (VR1) - CHO constitutive  
TRPV3  TRPV3 Olmsted syndrom CHO constitutive TRP Flyer
TRPV3  (mouse) TRPV3 Olmsted syndrom CHO constitutive  
TRPV4  TRPV4 Dwarfism, Neuropathy HEK 293 inducible TRP Flyer
TRPV4  (mouse) TRPV4 Dwarfism, Neuropathy CHO constitutive TRP Flyer
TRPM4 TRPM4 - CHO constitutive TRP Flyer
TRPM8  TRPM8 Pain sensation HEK 293 constitutive HEK TRPM8

 

Ligand gated ion receptors

 

GABAA Receptors

Target Gene Disorder Cell Type Expression Datasheet
GABA α1β2γ2 GABRA1 / GABRB2 / GABRG2 - CHO constitutive CHO GABA a1b2g2
GABA α2β2γ2 GABRA2 / GABRB2 / GABRG2 - HEK inducible  

Glutamate Receptors

Target Gene Disorder Cell Type Expression Datasheet
Kainate K2  GRIK2 - CHO constitutive CHO GRIK2
Kainate K2  GRIK2 - HEK 293 inducible HEK GRIK2
NMDAR1  GRIN1 Mental retardation CHO inducible HEK GRIN1
NMDA 1/2A  GRIN1/GRIN2A Epilepsy HEK 293 inducible HEK NMDA 2A
NMDA 1/2B  GRIN1/GRIN2B Depression HEK 293 inducible HEK NMDA 2B
NMDA 1/2D  GRIN1/GRIN2D - HEK 293 inducible HEK NMDA 2D

Acetylcholine Receptors

Target Gene Disorder Cell Type Expression Datasheet
nAChR α4β2 CHRNA4 / CHRNB2 - CHO constitutive CHO nAChR a4b2

P2X Receptors

Target Gene Disorder Cell Type Expression Datasheet
P2X1 P2rx1 - CHO constitutive P2X Cell lines
P2X2  P2rx2 - CHO constitutive P2X Cell lines
P2X2/3 P2rx2/P2rx3 - CHO constitutive P2X Cell lines
P2X3 P2rx3 - CHO constitutive P2X Cell lines
P2X4  P2rx4 - HEK 293 constitutive P2X Cell lines
P2X7  P2rx7 - HEK 293 constitutive P2X Cell lines

Glycine Receptors

Target Gene Disorder Cell Type Expression Datasheet
GlyRα1 (h)  GLRA1 - CHO constitutive  
GlyRα2 (r)  GLRA2 - CHO constitutive  
GlyRα3 (h)  GLRA3 Pain sensation HEK 293 inducible  
GlyRα3 (h)  GLRA3 Pain sensation CHO constitutive CHO GlyR a3
GlyRα3 (r)  GLRA3 Pain sensation CHO constitutive  

Serotonine Receptors

Target Gene Disorder Cell Type Expression Datasheet
5HT3A 5HT3A - CHO constitutive CHO 5HT3A

Acid sensing Receptors

Target Gene Disorder Cell Type Expression Datasheet
ASIC1 isoform a ACCN2 - CHO constitutive CHO ASIC1 isoform a
ASIC1 isoform b ACCN2 - CHO constitutive  
ASIC1 isoform c ACCN2 - CHO constitutive CHO ASIC1 isoform c
ASIC3  ACCN3 - CHO constitutive CHO ASIC 3

Miscellaneous Channels

Target Gene Disorder Cell Type Expression Datasheet
VDAC  VDAC1 - CHO constitutive  
PEPT1  SLC15A1 - MDCK constitutive  
Stargazin  CACNG2 Seizure disorders HEK 293 constitutive