Cambridge bioscience

Contact Person:
Vashu Pamnani

CiPA

Safety services

B'SYS performs tests to identify drug interactions with cardiac ion channels that act as target for QT prolongation.

Central nervous safety tests involve targets that are involved in addiction and neurotoxicity. B'SYS conducts assays to determine single concentration activities or concentration response relationships of test compounds.

  • Cardiac ion channel panel for identification and assessment of drugs that alter the QT interval
  • Cardiomyocyte action potential assays
  • Central nervous system panel for the identification of sedative, addictive or neurotoxic potential of test compounds.
  • Cardiotoxicity Screening (MEA, impedance)

Catalog

 

Cardiac Panel / Comprehensive in Vitro Proarrhytmia Assay (CiPA)

Nav1.5  (available as GLP assay) SCN5A
Kv4.3 KChiP KCND3 / KCNIP2
Cav1.2  (available as GLP assay) CACNA1C / CACNB2 / CACNA2D
hERG (available as GLP assay) KCNH2
Kv7.1/minK KCNQ1 / KCNQE1
Kir2.1 KCNJ2

 

Cardiac Panel (Automated Patch Clamping)

Nav1.5  (available as GLP assay) SCN5A
Kv4.3 KChiP KCND3 / KCNIP2
Cav1.2  (available as GLP assay) CACNA1C / CACNB2 / CACNA2D
hERG (available as GLP assay) KCNH2
Kv7.1/minK KCNQ1 / KCNQE1
Kir2.1 KCNJ2
Kv1.5 KCNA5
Cav3.2 CACNA1H

 

CNS Panel

Kv7.2  KCNQ2 
Kv7.2/7.3 (m current) KCNQ2/3
Nav1.1  SCN1A 
Nav1.2  SCN2A 
Nav1.3  SCN3A 
Nav1.6  SCN8A
Nav1.7  SCN9A 
Nav1.8  SCN10A 
Neuroblastoma whole sodium (TTX sensitive sodium channels) 
Cav2.1  CACNA1A / CACNB3 /CACNA2D2 or CACNA2D4 
ClC-2  CLCN2 
GABAA (α1β2γ2)  GABRA1 / GABRB2 / GABRG2 
GABAA (α1β3γ2)  GABRA1 / GABRB3 / GABRG2
GABAA (α2β2γ2)  GABRA2 / GABRB2 / GABRG2 
GABAA (α3β2γ2)  GABRA3 / GABRB2 / GABRG2 
GABAA (α4β3d) GABRA4 / GABRB3 / GABRD
GABAA (α5β2γ2)  GABRA5 / GABRB2 / GABRG2 
GABAA (α6β3d)
GABRA6 / GABRB3 / GABRD
Glycine (GlyRα3)
GLYRA3 
nAChR (α4β2) CHRNA4 / CHRNB2
nAChR (α7)  CHRNA7 
Serotonin 5HT3A  HTR3A 
P2X7 P2RX7 
AMPA  GRIA1 
Kainate K2 GRIK2
Kainate K2/K5 GRIK2/5
NMDA (NR1/2A)  GRIN1 / GRIN2A
NMDA (NR1/2B) GRIN1 / GRIN2B
NMDA (NR1 / 2C) GRIN1 / GRIN2C
NMDA (NR1/2D) GRIN1 / GRIN2D

 

Memory Panel

GABAA (α5β2γ2)  GABRA5 / GABRB2 / GABRG2
AMPA  AMPA1 
NMDA (NR1 / 2A)
GRIN1 / GRIN2A
NMDA (NR1 / 2B) GRIN1 / GRIN2B
nAchR (α4β2)  CHRNA4 / CHRNB2 
nAchR (α7)  CHRNA7 

 

Antiepileptic Panel

KV 7.2/7.3 (m current) KCNQ2/3
Kv7.2  KCNQ2 
Nav1.1 SCN1A 
Nav1.2  SCN2A 
Nav1.3  SCN3A 
Nav1.6  SCN8A 
Nav1.7  SCN9A 
Nav1.8 SCN10A 
Neuroblastoma whole sodium (TTX sensitive sodium channels) 
Cav2.1  CACNA1A / CACNB3 / CACNA2D2 or CACNA2D4 
ClC-2 CLCN2 20
GABAA (α1β2γ2)  GABRA1 / GABRB2 / GABRG2 
GABAA (α1β3γ2)  GABRA1 / GABRB3 / GABRG2
GABAA (α2β2γ2)  GABRA2 / GABRB2 / GABRG2 
GABAA (α3β2γ2)  GABRA3 / GABRB2 / GABRG2 
GABAA (α4β3d) GABRA4 / GABRB3 / GABRD
GABAA (α5β2γ2)  GABRA5 / GABRB2 / GABRG2 
GABAA (α6β3d) GABRA6 / GABRB3 / GABRD
GABAA (α1β2γ2) Fluorescence  GABRA1 / GABRB2 / GABRG2 
Glycine GlyRα3  GLRA3 
AMPA  AMPA1 
NMDA (NR1/2A) GRIN1  /GRIN2A
NMDA (NR1/2B) GRIN1 / GRIN2B

 

Pain Panel

GABAA (α1β2γ2) Fluorescence HTS  GABRA1 / GABRB2 / GABRG2 
GABAA (α1β2γ2)  GABRA1 / GABRB2 / GABRG2 
GABAA (α1β3γ2)  GABRA1 / GABRB3 / GABRG2
GABAA (α2β2γ2)  GABRA2 / GABRB2 / GABRG2 
GABAA (α3β2γ2)  GABRA3 / GABRB2 / GABRG2 
GABAA (α4β3d) GABRA4 / GABRB3 / GABRD
GABAA (α5β2γ2)  GABRA5 / GABRB2 / GABRG2 
GABAA (α6β3d) GABRA6 / GABRB3 / GABRD
Glycine (GlyRα3)  GLYRA3 
AMPA GRIA1 
NMDA (NR1/2A)  GRIN1  /GRIN2A 
NMDA (NR1/2B)  GRIN1 / GRIN2B 
TRPV1 TRPV1 (VR1) 
TRPV2  TRPV2 
Nav1.7 SCN9A
Nav1.8  SCN10A