CiPA

Swiss Quality in Ion channel Services

GABAA3β2γ2)

Gene: GABRA3 / GABRB2 / GABRG2

herg Standard throughput time 2-4 weeks (draft)
Source human
Expression system mammalian (LtK, HEK 293), stable expression
Method manual and automated patch-clamping
Quality level high quality functional assay
Reference positive allosteric modulator: Diazepam
  antagonist: Bicuculline (IC50: 623 nM)
References, further examples Midazolam
+  GABAA profiling for pesticides
+  Antinociceptive screening
+  Profiling for anticonvulsive / sedative / anxiolytic / memory effects