CiPA

Swiss Quality in Ion channel Services

Nav1.2

Gene: SCN2A

herg Standard throughput time 2-4 weeks (draft)
Source human
Expression system mammalian (CHO, HEK 293)
Method manual and automated patch-clamping
Quality level high quality functional assay
Reference Lidocaine (IC50: 89 µM)
+  Neuronal sodium channel assay
+  CNS toxicity / safety relevant ion channel test