CiPA

Swiss Quality in Ion channel Services

Nav1.7

Gene: SCN9A

nav1.7 Standard throughput time 2-4 weeks (draft)
Source human
Expression system mammalian (CHO, HEK 293)
Method manual and automated patch-clamping
Quality level high quality functional assay
Reference TTX (IC50: 54.8 nM)
References, further examples

Mibefradil, Lidocaine (IC50: 140.8 µM)

ProTX-II (1 nM, full block)

+  Neuronal sodium channel assay
+  Antinociceptive screening (CNS / dorsal root ganglion)
+  CNS toxicity / safety relevant ion channel test