CiPA

Swiss Quality in Ion channel Services

Nav1.5

Gene: SCN5A

nav1.5
Standard throughput time 2-4 weeks (draft)
Source human
Expression system mammalian (CHO), stable expression
Method manual and automated patch-clamping
Quality level high quality functional assay
Reference Quinidine (IC50: 13.6 µM), Propafenone (IC50: 1.5 µM), Carbamazepine (IC50: 59.2 µM), TTX (IC50: 6.0 µM),
References, further examples Mibefradil, Lidocaine, TTX
+  Cardiac toxicity / safety relevant ion channel test
+  Antiarrhythmic screening