CiPA

Swiss Quality in Ion channel Services

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Gene: SCN8A

herg Standard throughput time 2-4 weeks (draft)
Source human
Expression system mammalian (CHO, HEK 293)
Method manual and automated patch-clamping
Quality level high quality functional assay
Reference TTX (IC50: 7.3 µM)
References, further examples Mibefradil, Lidocaine
+  Neuronal sodium channel assay
+  Antinociceptive screening (CNS / dorsal root ganglion)
+  CNS toxicity / safety relevant ion channel test