CiPA

Swiss Quality in Ion channel Services

GABAA2β2γ2)

Gene: GABRA2 / GABRB2 / GABRG2

HEK GABA a2b2g2 Standard throughput time 2-4 weeks (draft)
Source human
Expression system mammalian (LtK, HEK 293), stable expression
Method manual and automated patch-clamping
Quality level high quality functional assay
Reference positive allosteric modulator: Diazepam
  antagonist: Bicuculline (IC50: 225.5 nM)
References, further examples Midazolam
+  GABAA profiling for pesticides
+  Antinociceptive screening
+  Profiling for anticonvulsive / sedative / anxiolytic / memory effects