Swiss Quality in Ion channel Services


Gene: KCNH2

hERG GLP Q&A top MVAL036 bottom MVAL038 Standard throughput time 2 weeks (draft report)
Source human
Expression system mammalian (HEK 293 / CHO)
Method manual patch-clamping
Assay temperature Room temperature
36°C ± 1
References Moxifloxacin (HEK293):
IC50 = 94.65µM
Moxifloxacin (CHO):
IC50 = 103.34µM
Ondansetron (HEK293):
IC50 = 1.50µM
Ondansetron (CHO):
IC50 = 2.25µM
Dofetilide (HEK293):
IC50 = 11.04nM
Dofetilide (CHO):
IC50 = 10.13nM
Additional options Solubility tests
Dose range finding
Full glass equipment
Additional Readouts Support of human readable raw data including quality parameter and ICH E14/SB7 report.
Dose formulation analysis can be provided as multisite study with a company on the same campus or any other GLP certified analytical lab.
Full validation reports are available on request.
For further information, please contact us at [email protected]