hERG GLP Q&A

Gene: KCNH2

	Standard throughput time	2 weeks (draft report)
	Source	human
	Expression system	mammalian (HEK 293 / CHO)
	Method	manual patch-clamping
	Assay temperature	Room temperature 36°C ± 1
	References	Moxifloxacin (HEK293): IC50 = 94.65µM Moxifloxacin (CHO): IC50 = 103.34µM Ondansetron (HEK293): IC50 = 1.50µM Ondansetron (CHO): IC50 = 2.25µM Dofetilide (HEK293): IC50 = 11.04nM Dofetilide (CHO): IC50 = 10.13nM
	Additional options	Solubility tests Dose range finding Full glass equipment
	Additional Readouts	Support of human readable raw data including quality parameter and ICH E14/SB7 report.
	Dose formulation analysis can be provided as multisite study with a company on the same campus or any other GLP certified analytical lab.
	Full validation reports are available on request.
	For further information, please contact us at [email protected]