Ion channel screening

• CNS fields: neuropathy, pain, mood, memory, sleep, epilepsy
• Cardiovascular fields: arrhythmia, hypertension
• Further fields: immunology, metabolism, PNS
• Techniques include patch-clamping and fluorescence assays
• Stem cell derived myocytes and neuronal lineage test systems

Safety Pharmacology

• High quality GLP Ion Channel Assays (ICH guided test strategies)
• Comprehensive in Vitro Proarrhytmia Assay (CiPA)
• Cardiac Ion Chanel Panel
• Ion Channel Trafficking Assays
• Serum Shift Assay
• Action Potential Assays
• High throughput quality screening
• Subtype selectivity screening

 

Design of Stable Cell Lines

• Production of test systems for high throughput screening
• From molecular biology to functional validation
• Seamless documentation from DNA to assay

Good Laboratory Practice

• Study completion according to GLP principles
• Quarterly QAU inspections of test facility
• Archiving of study records for at least 10 years