CiPA

Swiss Quality in Ion channel Services

KVLQT1/mink

Gene: KCNQ1 / KCNE1

Kv7.1/minK Standard throughput time 2-4 weeks (draft)
Source human
Expression system mammalian (HEK 293), stable expression
Method manual and automated patch-clamping
Quality level high quality functional assay
Reference Chromanol 293B (IC50: 6.2 µM)

References, further examples

HMR 1556 (IC50: 0.1 µM), Mefloquine (IC50: 3.6 µM)
+  Cardiac toxicity / safety relevant ion channel test
+  Antiarrhytmic screening