CiPA

Swiss Quality in Ion channel Services

GABAA1β2γ2)

Gene: GABRA1 / GABRB2 / GABRG2

gabaa a1b2g2 Standard throughput time 2-4 weeks (draft)
Source human
Expression system mammalian (LtK, CHO, HEK 293), stable expression
Method manual and automated patch-clamping and fluorescence (FlexStation/FLIPR)
Quality level high quality functional assay and fluorescence assay
Reference positive allosteric modulator: Diazepam
  antagonist: Bicuculline (IC50: 265 nM)
+  GABAA profiling for pesticides
+  Antinociceptive screening
+  Profiling for anticonvulsive / sedative / anxiolytic / memory effects