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Manual patch clamping
B‘SYS is equipped with state of the art patch-clamp technology. Our setups are equiped with systms for rapid drug application (Dyna Flow Y Rapid Solution Charger).
Further options for your experiments:
- Full glass equipment
- Temperature control
- Full human plasma or in the presence of BSA or other relevant proteins
Apllication schemes and assay conditions can be adapted for your needs.
Depending on the application scheme and the type of ion channel the manual setups at B'SYS allow the measurement of 20-50 compounds per day.
Whole-cell recordings or single-channel analysis in various expression systems (HEK 293, CHO, Neuroblastoma etc.) can be conducted to test the effects of drugs on voltage-gated or ligand-gated ion channels.
Please contact us for details or offers: info@bsys.ch
For details, please check our catalog.
Voltage gated ion channels Ligand gated ion channels
Voltage gated ion channels (VGIC)
Potassium Channel
| Kv1.1 | KCNA1 |
| Kv1.2 | KCNA2 |
| Kv1.3 | KCNA3 |
| Kv1.4 | KCNA4 |
| Kv1.5 | KCNA5 |
| Kv1.6 | KCN6A |
| Kv4.3 | KCND3 |
| Kv7.1/minK | KCNQ1 / MINK |
| Kv7.2 | KCNQ2 |
| Kv7.3 | KCNQ3 |
| Kv7.2/7.3 | KCNQ2/3 |
| Kv11.1 (hERG) | KCNH2 |
| Kir2.1 | KCNJ2 |
| Neuroblastoma whole potassium channels (N1E-115) | |
Sodium Channel
| Nav1.1 | SCN1A |
| Nav1.2 | SCN2A |
| Nav1.3 | SCN3A |
| Nav1.5 | SCN5A |
| Nav1.6 | SCN8A |
| Nav1.7 | SCN9A |
| Nav1.8 | SCN10A |
| Neuroblastoma whole sodium (TTX sensitive sodium channels) | |
Calcium Channel
| Cav1.2 | CACNA1C / CACNB2 / CACNA2D |
| Cav2.1 | CACNA1A / CACNB3 / CACNA2D2 or CACNA2D4 |
| Cav3.2 | CACNA1H |
| Neuroblastoma whole calcium (T- and L- type) | |
Chloride Channel
| ClC-2 | CLCN2 |
TRP Channels
| TRPA1 | TRPA1 |
| TRPM8 | TRPM8 |
| TRPV1 | TRPV1 (VR1) |
| TRPV2 | TRPV2 |
| TRPV4 | TRPV4 |
GABAA Receptors
| GABAA (α1β2γ2) | GABRA1 / GABRB2 / GABRG2 |
| GABAA (α1β3γ2) | GABRA1 / GABRB3 / GABRG2 |
| GABAA (α2β2γ2) | GABRA2 / GABRB2 / GABRG2 |
| GABAA (α3β2γ2) | GABRA3 / GABRB2 / GABRG2 |
| GABAA (α5β2γ2) | GABRA5 / GABRB2 / GABRG2 |
Glutamate Receptors
| AMPA | GRIA1 |
| NMDA (NR1/2A) | GRIN1/GRIN2A |
| NMDA (NR1/2B) | GRIN1/GRIN2B |
Acetylcholine Receptors
| nAChR (α7) | CHRNA7 |
| nAChR (α4β2) | CHRNA4 / CHRNB2 25 |
P2X Receptors
| P2X4 | P2RX4 |
| P2X7 | P2RX7 |
Glycine Receptors
| GlyRα3 | GLYRA3 |
Serotonine Receptors
| Serotonin | 5HT3A HTR3A |
Acid sensing Channels
| ASIC1a |
ACCN2 |
| ASIC1b |
ACCN2 |