CiPA

Swiss Quality in Ion channel Services

NaV1.5

Cell lines available: CHO, constitutive expression. Assays validated for manual and automated patch-clamp.

 

Manual patch-clamp:

Nav1.5cp

 

 

IC50 value (µM)

 

IC50 value (µM)

Propafenone

1.6

Carbamazepine

59.2

Quinidine

13.6

TTX

6.0

 

 

Automated patch-clamp (state dependent screening):

Nav1.5cp2

 

 

IC50 value (µM)

 

IC50 value (µM)

Resting 3rd

5.5

Fast inactivated

3.7

Slow inactivated

2.7