CiPA

Swiss Quality in Ion channel Services

hERG (IKr)

Cell lines available: HEK293 / CHO, constitutive / inducible expression. Assays validated for manual and automated patch-clamp.
GLP validated assay.

 

Manual patch-clamp:

hergcp

 

 

IC50 value

 

IC50 value

E-4031

11.6 nM

Terfenadine

15.8 nM

Dofetelide

11.7 nM

Ketokonazole

5.5 µM

Flecainide 1.9 nM Cisapride 7.3 nM
Amiodarone 0.2 µM Haloperidol 19.5 nM

 

 

Automated patch-clamp:

hergcp2

 

 

IC50 value (µM)

Verapamil

0.8