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High Quality Ion Channel Drug Discovery
 Catalogue 2009
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Drug Screening
… CNS fields: neuropathy, pain, mood, memory, sleep, epilepsy
… Cardiovascular fields: arrhythmia, hypertension
… Further fields: immunology, metabolism, PNS
… Techniques include patch-clamping and fluorescence assays
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HERG Safety
… High quality GLP testing
… ICH guided test strategies
… High throughput quality screening
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Design of Stable Cell Lines
… Production of test systems for high throughput screening
… From molecular biology to functional validation
… Seamless documentation from DNA to assay
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Good Laboratory Practice
… Study completion according to GLP principles
… Quarterly QAU inspections of test facility
… Archiving of study records for at least 10 years
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Fields of interest:
Ion channel screening, glp, hERG,herg channel, potassium channel, HEK, CHO, CRO, S7A S7B, QT prolongation, cardiac action potential.
QT prolongation, pharmacology, safety pharmacology, herg screening, Swissmedic, in vivo, in vitro, preclinical safety assessment.
patch-clamp, IKr, cisapride, terfenadine, astemizole, grepafloxacin, QT interval, cardiac arrhythmias, FDA, myocytes, herg liability.
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