Cambridge bioscience

Contact Person:
Vashu Pamnani

CiPA

Cell Lines

All recombinant ion channel targets are fully validated and available for screening purposes. B‘SYS continuously expands its library of ion channels. Please contact us for more information about other ion channel targets not outlined in the table below. info@bsys.ch

Target Gene Disorder Cell Type ExpressionDatasheet
hERG
KCNH2 LQT Syndrome 2 HEK 293 inducible HEK-Tet hERG
hERG  KCNH2 LQT Syndrome 2 HEK 293 constitutive HEK 293 hERG
hERG  KCNH2 LQT Syndrome 2 CHO inducible CHO-Tet hERG
hERG  KCNH2 LQT Syndrome 2 CHO constitutive CHO-Tet hERG
hERG Duo  KCNH2 LQT Syndrome 2 CHO constitutive CHO hERG DUO
CaV1.2  CACNA1C/CACNB2/ CACNA2D - HEK 293 inducible HEK CaV1.2
CaV3.2  CACNA1H - HEK 293 constitutive HEK CaV3.2
KVLQT1  KCNQ1 LQT Syndrome 1/5 HEK 293 constitutive HEK CaV3.2
KVLQT1/minK  KCNQ1/KCNE1 LQT Syndrome 1/5 HEK 293 inducible HEK KvLQT1/minK
KVLQT1/minK KCNQ1/KCNE1 LQT Syndrome 1/5 CHO constitutive CHO KvLQT1/minK
KV1.1  KCNA1 Seizure disorders CHO constitutive CHO Kv1.x
KV1.2  KCNA2 Seizure disorders CHO constitutive CHO Kv1.x
KV1.3  KCNA3 Immune system related CHO constitutive CHO Kv1.3
KV1.4  KCNA4 - CHO constitutive CHO Kv1.x
KV1.5  KCNA5 Heart function CHO constitutive CHO Kv1.x
KV1.6  KCNA6 - CHO constitutive CHO Kv1.x
KV2.1  KCNB1 - CHO constitutive CHO Kv2.1
KV2.1 KCNB1   HEK 293 inducible  
KV2.2  KCNB2 - CHO constitutive
KV2.2  KCNB2 - HEK 293 inducible
KV4.3  KCND3 - CHO constitutive CHO Kv4.3
KV4.3 KChip  KCND3 - CHO constitutive CHO Kv4.3 KChIP
KV7.1  KCNQ1 - HEK 293  inducible
KV7.2  KCNQ2 Epilepsy CHO constitutive CHO Kv7.2
KV7.3  KCNQ3 Epilepsy
CHO
constitutive
NaV1.3  SCN3A Epilepsy / Pain CHO constitutive
NaV1.4  SCN4A - HEK inducible
NaV1.5  SCN5A LQT Syndrome 3 CHO constitutive CHO NaV1.5
NaV1.5 duo  SCN5A LQT Syndrome 3 CHO constitutive CHO NaV1.5 DUO
NaV1.8  SCN10A/SCN3B - CHO
constitutive
CHO NaV1.8
Kir2.1  KCNJ2 LQT Syndrome CHO constitutive CHO Kir2.1
VDAC  VDAC1 -
CHO constitutive

CFTR  CFTR -
CHO constitutive

CFTR  CFTR -
HEK 293 inducible
HCN4  HCN4 -
HEK 293 inducible HEK HCN4
GlyRα3 (h)  GLRA3 Pain sensation HEK 293 inducible
GlyRα3 (r)  GLRA3 Pain sensation CHO constitutive CHO GlyR a3
TRPV1  TRPV1 (VR1) - CHO constitutive CHO TRPV 1
TRPV3  TRPV3 Olmsted syndrom CHO constitutive
TRPV3  TRPV3 Olmsted syndrom HEK 293 inducible
TRPV4  TRPV4 Dwarfism, Neuropathy HEK 293 inducible
TRPM8  TRPM8 Pain sensation HEK 293 constitutive
TRPM8  TRPM8 Pain sensation CHO constitutive
P2X2  P2rx2 - CHO inducible CHO P2X2
P2X4  P2rx4 - HEK 293 constitutive HEK P2X
P2X7  P2rx7 - HEK 293 constitutive HEK P2X
5HT3A 5HT3A - CHO constitutive CHO 5HT3A
PEPT1  SLC15A1 - MDCK constitutive
Stargazin  CACNG2 Seizure disorders
HEK 293 constitutive
ASIC1a  ACCN2 - CHO constitutive CHO ASIC 1a
ASIC1b  ACCN2 - CHO constitutive CHO ASIC 1b
ASIC3  ACCN3 - CHO constitutive CHO ASIC 3
NMDA 1/2A  GRIN1/GRIN2A Epilepsy HEK 293 inducible HEK NMDA 2A
NMDA 1/2B  GRIN1/GRIN2B Depression
HEK 293 inducible HEK NMDA 2B
NMDA 1/2D  GRIN1/GRIN2D - HEK 293 inducible HEK NMDA 2D
NMDAR1  GRIN1 Mental retardation CHO inducible HEK GRIN1
Kainate K2  GRIK2 - CHO constitutive
Kainate K2  GRIK2 - HEK 293 inducible
GABA α1β2γ2 GABRA1 / GABRB2 / GABRG2 - CHO constitutive

 

KV7.2